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Research Preview — Unreviewed AI Research

Omeprazole

Proton pump inhibitor (PPI), substituted benzimidazole, irreversible H+/K+-ATPase inhibitor

Also sold as Prilosec.

Researched 9/3/2026

Evidence summary

Qualifying findings
1
Interactions and timing
0
Searched, nothing found
0
Verified cited sources
2 of 2
Human review
Not yet reviewed
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Overview

Research Preview — Unreviewed AI Research

AI-assisted Research Preview - not yet human-reviewed and not part of Published Knowledge.

This is automated research that has not yet been reviewed by a person. It is not MyDeficiencies published knowledge, it is not medical advice, and it may be incomplete or wrong. It has been added to our editorial review queue.

Proton pump inhibitor (PPI), substituted benzimidazole, irreversible H+/K+-ATPase inhibitor.

Researched 9/3/2026 · Adversarial review ran: 1 confirmed, 0 scope corrections, 0 rejected.

2 of 2 cited sources were confirmed to exist as described. That check confirms the source is real, not that it supports the claim.

What the research found

Evidence for this exact medication is kept strictly apart from evidence that comes only from its drug class.

Direct evidence for this medication

Measured decrease in nutrient status

Vitamin B12 (cobalamin)

exact entity

Direct evidence for this medication

A decrease in Vitamin B12 (cobalamin) was reported in people taking Omeprazole. This is a measured decrease in status, and is not by itself a diagnosis of deficiency. The evidence relationship is direct: it was measured in people taking Omeprazole itself. Discuss with your prescriber before changing anything.

2 cited sources and detail

Human studies that measured this nutrient in people taking this exact medication.

Relationship:
decrease in most positive studies; no significant change in some studies
Outcome measured:
Measured decrease in nutrient status
Study population:
human studies
Agreement:
3 supporting, 0 contradicting

What was measured: A decrease in Vitamin B12 (cobalamin) was reported in people taking Omeprazole. This is a measured decrease in status, and is not by itself a diagnosis of deficiency.

Proposed mechanism: Gastric acid is required to cleave dietary protein-bound B12 for absorption; sustained acid suppression is proposed to impair this step. A mechanism explains how an effect could occur. It is not itself a measured clinical outcome.

2 of 2 cited sources were checked and found to support this specific claim. A source existing is not the same as a source supporting the claim.

Why it is here: 2 verified human studies measured this nutrient directly in people taking this medication.

Evidence limitations

What this cannot tell you

  • This is automated research that has not yet been reviewed by a person. It is not MyDeficiencies published knowledge, it is not medical advice, and it may be incomplete or wrong. It has been added to our editorial review queue.
  • This packet is limited to human evidence located via the searches actually performed on 2026-09-03 and does not represent an exhaustive systematic review.
  • Evidence scope varies from exact-medication (omeprazole) trials to drug-class and related-drug (esomeprazole) trials; these are labeled separately and never merged.
All research limitations for this run
  • Most fracture and hypomagnesemia evidence is observational or based on spontaneous adverse event reporting, which cannot establish causation.
  • Controlled human trials on calcium and iron absorption directly conflict with each other depending on population age, health status, and baseline nutrient status.
  • No claim in this packet should be read as instruction to start, stop, or change any medication or supplement.
  • 16 of 25 cited sources could not be confirmed to exist as described. Claims resting only on those sources are withheld.
  • Several claims rely on sources that were unreachable or not assessed by the system verifier, limiting confidence below what the original packet proposed
  • Fracture and hypomagnesemia evidence remains observational or spontaneous-report based throughout
  • Controlled absorption trials for calcium and iron conflict depending on population, so no single directional conclusion is supportable
  • Packet declared no truncation this run but multiple cited sources could not be retrieved for content verification
  • 13 of 16 sources that were confirmed to exist were not confirmed to support the specific claim they were attached to. Existence is not support, and those claims are withheld.

AI-assisted Research Preview - not yet human-reviewed and not part of Published Knowledge. Educational information only. Not medical advice, diagnosis or treatment. Talk to your prescriber or pharmacist before changing any medication or supplement.

Sources

Only sources attached to information shown above are listed here.

  • Association of Vitamin B12 deficiency with long-term PPIs use: A cohort study

    2022 · Cohort study · human study

    DOI 10.1016/j.amsu.2022.104762· identifier confirmed to exist (DOI)

    https://doi.org/10.1016/j.amsu.2022.104762

  • Association of Vitamin B12 deficiency with long-term PPIs use: A cohort study

    2022 · Cohort study · human study

    DOI 10.1016/j.amsu.2022.104762· identifier confirmed to exist (DOI)

    https://doi.org/10.1016/j.amsu.2022.104762
  • Existence of a source and support for a claim are checked separately. A confirmed identifier means the record is real, not that it supports the statement it is cited for.

Questions for your clinician

These are conversation prompts, not findings about you.

  • Could Omeprazole affect any nutrients over time in my situation?
  • Are there symptoms or risk factors that would make further evaluation appropriate?
  • Could diet, other medications, or health conditions affect this relationship?
  • Would laboratory testing be clinically appropriate for me?
  • Are there medication or supplement interactions I should understand?

Review status

Human review

Published Knowledge is human-reviewed. Research Previews are clearly labeled and have not yet completed human review.

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Derived from acceptance run on-demand research run 2f0f0cbf-4d1a-4127-8a36-d1d665e69708 (49594e14685c).