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Beta Blocker (Cardiovascular)

Metoprolol

Also sold as Lopressor

Associated with reduced CoQ10 and possible melatonin disruption.

This page provides educational information about possible medication-related nutrient relationships. It does not diagnose a deficiency, establish that this medication caused a symptom, or replace qualified medical care.
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Overview

About Metoprolol

Metoprolol belongs to the Beta Blocker (Cardiovascular) class. Recognized brand names include Lopressor.

Associated with reduced CoQ10 and possible melatonin disruption.

MyDeficiencies does not provide dosing instructions, adverse-effect lists, or personalized medical advice. Always follow the guidance of your prescribing clinician and pharmacist.

Nutrient relationships

Possible Nutrient Relationships

  • CoQ10

    Moderate Evidence

    Mitochondrial bioenergetics in cardiac muscle.

    Available evidence suggests Metoprolol may affect coq10 status. Individual responses vary.

How to read this page

Evidence Strength

Evidence labels reflect the current strength of available research, not a guarantee of individual outcomes:

  • Stronger Evidence — Consistent, replicated evidence across multiple well-designed studies.
  • Moderate Evidence — Supportive evidence with some variability across populations or study designs.
  • Emerging Evidence — Early or mechanistic signals that warrant continued study.

Read our full evidence framework →

Proposed mechanisms

How These Relationships May Occur

Blocks β1-adrenergic receptors; reduces CoQ10 status and may suppress nocturnal melatonin release.

A proposed mechanism explains how a relationship might occur. It does not prove that a clinically meaningful deficiency occurs in every individual.

Body systems

Body Systems That May Be Relevant

  • Mitochondrial Energy

    Moderate Evidence

    Cofactors that support mitochondrial energy production may be relevant.

  • Oxygen & ATP

    Emerging Evidence

    Oxygen delivery and cellular energy metabolism may be relevant.

Symptoms and context

Symptoms and Context

Discussions around Metoprolol sometimes reference: Sleep changes, Fatigue.

Symptoms such as fatigue, weakness, numbness, digestive changes, or mood changes can have many possible explanations. This page does not determine their cause.

Combinations reviewed

Reviewed Combinations

  • Metoprolol + Atorvastatin

    Moderate Evidence

    Both reduce CoQ10 status — statin blocks endogenous synthesis, beta-blocker depletes pool.

    Higher risk of fatigue, exercise intolerance, and statin-associated muscle symptoms.

For your next visit

Questions You May Want to Discuss

  • Could Metoprolol affect any nutrients over time in my situation?
  • Are there symptoms or risk factors that would make further evaluation appropriate?
  • Could diet, other medications, or health conditions affect this relationship?
  • Would laboratory testing be clinically appropriate for me?
  • Are there medication or supplement interactions I should understand?

These are conversation starters, not recommendations to request a specific test, supplement, or medication change.

Research

Research and Sources

Formal citations for Metoprolol are being catalogued. See our Research Center for evidence standards and methodology.

See our evidence methodology for how sources are evaluated.

View MyDeficiencies research updates(research revisions are tracked centrally, including for Metoprolol)
Related nutrients

Related Nutrients

  • CoQ10
    Moderate Evidence
Ready to go deeper

Explore Metoprolol in Your Report

Add Metoprolol to a MyDeficiencies analysis to view its reviewed nutrient relationships alongside other medications, supplements, symptoms, and relevant context.

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Educational only. Not a diagnosis. Not a substitute for qualified medical care.