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ACE Inhibitor (Blood Pressure)

Lisinopril

Also sold as Zestril

May increase urinary zinc loss; monitor taste changes and immune resilience.

This page provides educational information about possible medication-related nutrient relationships. It does not diagnose a deficiency, establish that this medication caused a symptom, or replace qualified medical care.
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Overview

About Lisinopril

Lisinopril belongs to the ACE Inhibitor (Blood Pressure) class. Recognized brand names include Zestril.

May increase urinary zinc loss; monitor taste changes and immune resilience.

MyDeficiencies does not provide dosing instructions, adverse-effect lists, or personalized medical advice. Always follow the guidance of your prescribing clinician and pharmacist.

Nutrient relationships

Possible Nutrient Relationships

  • Zinc

    Moderate Evidence

    Immune function, wound healing, and taste perception.

    Available evidence suggests Lisinopril may affect zinc status. Individual responses vary.

How to read this page

Evidence Strength

Evidence labels reflect the current strength of available research, not a guarantee of individual outcomes:

  • Stronger Evidence — Consistent, replicated evidence across multiple well-designed studies.
  • Moderate Evidence — Supportive evidence with some variability across populations or study designs.
  • Emerging Evidence — Early or mechanistic signals that warrant continued study.

Read our full evidence framework →

Proposed mechanisms

How These Relationships May Occur

ACE inhibition increases urinary excretion of zinc and may modestly alter trace mineral balance.

A proposed mechanism explains how a relationship might occur. It does not prove that a clinically meaningful deficiency occurs in every individual.

Body systems

Body Systems That May Be Relevant

  • Copper–Iron Balance

    Emerging Evidence

    Trace mineral balance may be relevant.

Combinations reviewed

Reviewed Combinations

  • Lisinopril + Losartan

    Stronger Evidence

    Dual RAAS blockade — ACE inhibitor + ARB acting on the same pathway.

    Significant risk of hyperkalemia, hypotension, and acute kidney injury. Typically contraindicated.

For your next visit

Questions You May Want to Discuss

  • Could Lisinopril affect any nutrients over time in my situation?
  • Are there symptoms or risk factors that would make further evaluation appropriate?
  • Could diet, other medications, or health conditions affect this relationship?
  • Would laboratory testing be clinically appropriate for me?
  • Are there medication or supplement interactions I should understand?

These are conversation starters, not recommendations to request a specific test, supplement, or medication change.

Research

Research and Sources

See our evidence methodology for how sources are evaluated.

View MyDeficiencies research updates(research revisions are tracked centrally, including for Lisinopril)
Related nutrients

Related Nutrients

  • Zinc
    Moderate Evidence
Ready to go deeper

Explore Lisinopril in Your Report

Add Lisinopril to a MyDeficiencies analysis to view its reviewed nutrient relationships alongside other medications, supplements, symptoms, and relevant context.

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Educational only. Not a diagnosis. Not a substitute for qualified medical care.