Skip to main content
MyDeficienciesMyDeficiencies
All medications
Supported by MyDeficiencies
Anticonvulsant / Neuropathic Pain

Gabapentin

Also sold as Neurontin

May reduce vitamin D and folate status with chronic use.

This page provides educational information about possible medication-related nutrient relationships. It does not diagnose a deficiency, establish that this medication caused a symptom, or replace qualified medical care.
Analyze This Medication View Research
Overview

About Gabapentin

Gabapentin belongs to the Anticonvulsant / Neuropathic Pain class. Recognized brand names include Neurontin.

May reduce vitamin D and folate status with chronic use.

MyDeficiencies does not provide dosing instructions, adverse-effect lists, or personalized medical advice. Always follow the guidance of your prescribing clinician and pharmacist.

Nutrient relationships

Possible Nutrient Relationships

  • Vitamin D

    Emerging Evidence

    Immune and bone regulation.

    Available evidence suggests Gabapentin may affect vitamin d status. Individual responses vary.

  • Folate

    Emerging Evidence

    Methylation and red blood cell formation.

    Available evidence suggests Gabapentin may affect folate status. Individual responses vary.

How to read this page

Evidence Strength

Evidence labels reflect the current strength of available research, not a guarantee of individual outcomes:

  • Stronger Evidence — Consistent, replicated evidence across multiple well-designed studies.
  • Moderate Evidence — Supportive evidence with some variability across populations or study designs.
  • Emerging Evidence — Early or mechanistic signals that warrant continued study.

Read our full evidence framework →

Proposed mechanisms

How These Relationships May Occur

Binds α2δ subunit of voltage-gated calcium channels; chronic use is associated with reductions in vitamin D and folate status.

A proposed mechanism explains how a relationship might occur. It does not prove that a clinically meaningful deficiency occurs in every individual.

Symptoms and context

Symptoms and Context

Discussions around Gabapentin sometimes reference: Brain fog, Fatigue.

Symptoms such as fatigue, weakness, numbness, digestive changes, or mood changes can have many possible explanations. This page does not determine their cause.

Combinations reviewed

Reviewed Combinations

  • Gabapentin + Sertraline

    Emerging Evidence

    Both can be CNS depressants; additive sedation and cognitive slowing.

    Monitor for excessive drowsiness, dizziness, or impaired coordination.

For your next visit

Questions You May Want to Discuss

  • Could Gabapentin affect any nutrients over time in my situation?
  • Are there symptoms or risk factors that would make further evaluation appropriate?
  • Could diet, other medications, or health conditions affect this relationship?
  • Would laboratory testing be clinically appropriate for me?
  • Are there medication or supplement interactions I should understand?

These are conversation starters, not recommendations to request a specific test, supplement, or medication change.

Research

Research and Sources

Formal citations for Gabapentin are being catalogued. See our Research Center for evidence standards and methodology.

See our evidence methodology for how sources are evaluated.

View MyDeficiencies research updates(research revisions are tracked centrally, including for Gabapentin)
Related nutrients

Related Nutrients

  • Vitamin D
    Emerging Evidence
  • Folate
    Emerging Evidence
Ready to go deeper

Explore Gabapentin in Your Report

Add Gabapentin to a MyDeficiencies analysis to view its reviewed nutrient relationships alongside other medications, supplements, symptoms, and relevant context.

Analyze This Medication Browse All Medications

Educational only. Not a diagnosis. Not a substitute for qualified medical care.